Tahaa – Polynesia

ßhCGs in trophoblastic diseases

SOGC/GOC Clinical Guideline #408, January 2021

  • Serum hCG is strongly correlated with tumor burden; it therefore constitutes an important and useful marker in the diagnosis and treatment of GTN.
  • The hCG glycoprotein consists of a single β subunit and a ⍺ subunit shared with other hormones, including thyroid stimulating hormone (TSH) and luteinizing hormone (LH).
  • Overstimulation from elevated hCG levels (usually >100,000 mIU/ml) can lead to the development of ovarian lutein cysts, hyperemesis gravidarum, pre-eclampsia, and hyperthyroidism.
  • Commercially available hCG tests detect some of the different forms of hCG. It is possible to observe a variation in the hCG levels detected when using different hCG tests during the follow-up of patients with GTN.

2021. Guideline No. 408: Management of Gestational Trophoblastic Diseases. Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier Ph. J Obstet Gynaecol Can;43(1):91-105.

Modified on 12/23/2023