Interpretation grid according to the GRADE methodological framework

Strength of recommendations
Strong	High confidence in the relationship between the expected benefits and risks of the intervention, i.e. that the benefits of an intervention outweigh the risks or that the risks outweigh the expected benefits.
Conditional (weak)	The expected benefits of an intervention probably outweigh the risks (in favor) or the risks probably outweigh the expected benefits (against).
Quality of the evidence body
Big	Confidence that the actual effect is close to the estimated effect.
Average	Moderate confidence in the estimated effect: The actual effect is probably close to the estimated effect, but it is possible that it differs significantly.
Weak	Limited confidence in estimated effect: The actual effect may be significantly different from the estimated effect.
Very weak	Very little confidence in the estimated effect: The actual effect is likely very different from the estimated effect.

• Translation adapted from the English version of Table 5.1, GRADE Handbook (2013) ,
• Conditional (weak) recommendations should not be misinterpreted as inconclusive data or uncertainty in the recommendation.

Evaluation and interpretation of recommendations , by target audience

Assessment or interpretation	Strong recommendation, “We recommend…”, “We recommend not…”	Conditional recommendation “We suggest…”, “We suggest not…”
Committee evaluation of the directive	It is clear to the committee that the expected net effects of one strategy outweigh the effects of the alternative strategy.	It is less clear to the committee whether the expected net effects of a strategy outweigh the effects of the alternative strategy.
Consequences for patients	Most people in this situation would want the recommended course of action to be followed; few people wouldn't want it.	Most people in this situation would want one to follow the suggested course of action, but many would not.
Consequences for clinicians	Most people should have this procedure	Clinicians must recognize that different choices will be indicated for each patient and that they must help each person make a decision that respects their values ​​and preferences.
Consequences for decision-makers	It is possible to implement this recommendation as a policy for most situations. Agreeing with this recommendation according to the clinical guideline can serve as a quality criterion or performance indicator.	Policy development will require extensive participation and discussion by various stakeholders.

• Translation adapted from the English version of Table 5.1, GRADE Handbook (2013) ,