Pathology of PSN, EPS and GTN

EntityKey featureOther histologic features
Placental site nodule (PSN)paucicellular, hyaline materialno mitotic activity
Exaggerated placental site (EPS)abundant intermediate trophoblasts - between muscleno mitotic activity
Placental site trophoblastic tumor (PSTT)abundant cytoplasm - not clear, dyscohesive+/- multinucleation
Epithelioid trophoblastic tumor (ETT)nests of cells in hyaline stromaeosinophilic cytoplasm, central nucleus
Choriocarcinomapolygonal cells with clear cytoplasm (cytotrophoblasts)multinucleated cells with smudged nuclei (syncytiotrophoblasts), no chorionic villi

EntityHCIDDx
Placental site nodule (PSN)p16 -ve, MIB1 lowEPS, squamous carcinoma
Exaggerated placental site (EPS)MIB1 ~0%PSTT, PSN
Placental site trophoblastic tumor (PSTT)MIB1 high, p63 -ve, CD146 +veEPS, choriocarcinoma
Epithelioid trophoblastic tumor (ETT)MIB1 low, p63 +ve, CD146 -vesquamous cell carcinoma
ChoriocarcinomaßhCG +ve, p63 +veinvasive hydatidiform mole, PSTT

Modified on 12/23/2023