Cell origins and phenotypes
| Lesion | Cell origin | trophoblast | Phenotype | Proliferation Index |
|---|---|---|---|---|
| Choriocarcinoma | Cytotrophoblast Syncytiotrophoblast | Neoplastic | hCG | > 90% |
| Complete hydatidiform mole | Cytotrophoblast Syncytiotrophoblast | Hyperplastic | hCG Loss P57/KIP2 | 40% |
| Placental site trophoblastic tumor | Implantation site trophoblast | Neoplastic | hPL Mel-CAM = CD146 | 10-30% |
| Exaggerated placental site | Implantation site trophoblast | Normal | hPL Mel-CAM = CD146 | < 1% |
| Epithelioid trophoblastic tumor | membrane trophoblast | Neoplastic | P63 PLAP Inhibin Ecad EGFR | 10-30% |
| Placental site nodule | membrane trophoblast | Undetermined | P63 PLAP Inhibin Ecad EGFR | < 5% |
2018.A. L'Herminé-Coulomb, Trophoblast tumors, 31 Dec. 2018 Correspondences in Onco-Theranostics – Vol. VII – n° 4 – October-November-December 2018
Modified on 12/23/2023