Pathology of moles and abortus
| Type of mole | Gross | Nuclear atypia | Chorionic villi | IHC | DNA content |
|---|---|---|---|---|---|
| Partial mole | grape-like clusters | +/- | large villi, villi with cisterns, villi with cytotrophoblastic inclusions | p57(KIP2) +ve | Maternal & paternal, tripoid |
| Complete mole | "snowstorm" | +/- ? | Yes, all abnormal | p57(KIP2) -ve | Paternal, diploid |
| Choriocarcinoma | hemorrhagic, necrotic | marked | none | beta-hCG +ve | ? |
| Entity | Chorionic villi (outline) | Cisterns | Blood vessels | Nucleated RBCs | p57 / Ki-67[2] staining ‡ | Ploidy |
|---|---|---|---|---|---|---|
| Complete mole | weird; often not ovoid; fissures/slit-like gaps | well-developed | canalicular (thin walled) / few (???) | rare | -ve / ~70% | diploid / tetraploid |
| Partial mole | jagged, still quasi ovoid | poorly developed / small | here | common | +ve / ~70% | triploid |
| Hydropic abortus | smooth | poorly developed / small | common | common | +ve / ~20% | diploid |
Modified on 12/23/2023