Monochemotherapy protocols
SOGC/GOC Clinical Guideline #408, January 2021
| Protocol | Dosage |
|---|---|
| methotrexate | |
| 8 days | 1 mg/kg IM q48 hr x 4; Folinic acid 30 mg po q 48 hr x 4 (30 hr after MTX) repeat every 14 d. |
| 5 days | 0.4 mg/kg (max. 25 mg) IV or IM daily x 5 days. repeat every 14 days. |
| Weekly | 30-50 mg/m2 IM repeat weekly |
| High dose | 600mg/m2 |
| Dactinomycin | |
| At 2 weeks | 1.25 mg/m2 IV (max. 2 mg) repeat every 14 days. |
| 5 days | 9-13 mcg/kg (max. 0.5 mg) IV x 5 d. repeat every 14 days. |
2021. Guideline No. 408: Management of Gestational Trophoblastic Diseases. Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier Ph. J Obstet Gynaecol Can;43(1):91-105.
Modified on 12/23/2023